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IDT publications

Peer-reviewed articles published by IDT scientists. Filter using one or more categories to focus on specific topics.

169 Citations found

Dallas A, Ge Q, Ilves H, Kumar P, Shorenstein J, Kazakov SA, Cuellar TL, McManus MT, Behlke MA, Johnston BH. (2012) Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing. Nucleic Acids Res, 40 : 9255–9271.
Huang YZ, Hernandez FJ, Gu B, Stockdale KR, Nanapaneni K, Scheetz TE, Behlke MA, Peek AS, Bair T, Giangrande PH, McNamara JO.. (2012) RNA aptamer-based functional ligands of the neurotrophin receptor, TrkB. Mol Pharmacol, 82 : 623–635.
Weinstein S, Emmanuel R, Jacobi AM, Abraham A, Behlke MA, Sprague AG, Novobrantseva T, Nagler, A, Peer D. (2012) RNA inhibition highlights Cyclin D1 as a potential therapeutic target for Mantle Cell Lymphoma. PLoS ONE, 7 : e43343.
Khairuddin N, Gantier MP, Blake SJ, Wu SY, Behlke MA, Williams BR, McMillan NA. (2012) SiRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo. Immunol Cell Biol, 90 : 187–196.
Kim N, Jiang D, Jacobi AM, Lennox KA, Rose SD, Behlke MA, Salem AK. (2012) Synthesis and characterization of mannosylated pegylated polyethylenimine as a carrier for siRNA. Int J Pharm, 427 : 123–133.
Rose S, Behlke MD. (2012) Synthetic dicer-Substrate siRNAs as triggers of RNA interference. In: RNA Interference from Biology to Therapeutics, 1 : 31–56.
Walk RM, Elliot ST, Blanco FC, Snyder JA, Jacobi AM, Rose SD, Behlke MA, Salem AK, Vukmanovic S, Sandler AD. (2012) T-cell activation is enhanced by targeting IL-10 cytokine production in toll-like receptor- stimulated macrophages. ImmunoTargets and Therapy, 1 : 13–23.
Sakurai K, Amarzguioui M, Kim DH, Alluin J, Heale B, Song MS, Gatignol A, Behlke MA, Rossi JJ. (2011) A role for human Dicer in pre-RISC loading of siRNAs. Nucleic Acids Res, 39 : 1510–1525.
Devor EJ, Huang L, Wise A, Peek AS, Samallow PB. (2011) An X chromosome microRNA cluster in the marsupial species Monodelphis domestica. J Hered, 102 : 577–583.
Gantier MP, McCoy CE, Rusinova I, Saulep D, Wang D, Xu D, Irving AT, Behlke MA, Hertzoq PJ, Mackay F, Williams BR. (2011) Analysis of microRNA turnover in mammalian cells following Dicer1 ablation. Nucleic Acids Res, 39 : 5692–5703.
Lennox KA, Behlke MA. (2011) Chemical modification and design of anti-miRNA oligonucleotides. Gene Ther, 18 : 1111–1120.
You Y, Tataurov AV, Owczarzy R. (2011) Measuring thermodynamic details of DNA hybridization using fluorescence. Biopolymers, 95 : 472–486.
Melkman-Zehavi T, Oren R, Kredo-Russo S, Shapira T, Mandelbaum AD, Rivkin N, Nir T, Lennox KA, Behlke MA, Dor Y, Hornstein E. (2011) miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressor. EMBO J, 30 : 835–845.
Thiel WH, Bair T, Wyatt-Thiel K, Dassie, JP, Rockey WM, Howell CA, Liu XY, Dupuy AJ, Huang L, Owczarzy R, Behlke MA, McNamara JO, Giangrande PH. (2011) Nucleotide bias observed with a short SELEX RNA aptamer library. Nucleic Acid Ther, 21 : 253–263.
Dobosy JR, Rose SD, Beltz KR, Rupp SM, Powers KM, Behlke MA, Walder JA. (2011) RNase H-dependent PCR (rhPCR): improved specificity and single nucleotide polymorphism detection using blocked cleavable primers. BMC Biotechnol, 11 : 1–18.
Michel CI, Holley CL, Scruggs BS, Sidhu R, Brookheart RT, Listenberger LL, Behlke MA, Ory DS, Schaffer JE. (2011) Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress. Cell Metab, 14 : 33–44.
Owczarzy R, You Y, Groth CL, Tataurov AV. (2011) Stability and mismatch discrimination of locked nucleic acid-DNA duplexes. Biochem, 50 : 9352–9367.

New nearest-neighbor parameters correctly forecast the positive and negative effects of LNAs on mismatch discrimination. Specificity is enhanced in a majority of sequences and is dependent on mismatch type and adjacent base pairs.

Rockey WM, Huang L, Kloepping KC, Baumhover NJ, Giangrande PH, Schultz MK. (2011) Synthesis and radiolabeling of chelator-RNA aptamer bioconjugates with copper-64 for targeted molecular imaging. Bioorg Med Chem, 19 : 4080–4090.
Lennox KA, Behlke MA. (2010) A direct comparison of anti-microRNA oligonucleotide potency. Pharm. Res, 27 : 1788–1799.
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